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Colloquium - Ohler

Computational Sequence Analysis and Eukaryotic Gene Regulation
Massachusetts Institute of Technology

The expression of individual genes in a complex organism requires an intricate network of control mechanisms to activate a gene under the right conditions. Different control levels encompass the transcription of genes into pre-messenger RNA, splicing of the pre-mRNA into a mature mRNA, and the translation of the mRNA into a protein product. Computational biology methods, and here especially approaches for pattern recognition, have helped tremendously to gain insight into these processes.

In my talk, I will present work related to these three aspects: (1) Computational recognition and analysis of core promoter sequences in Drosophila, which lead to the annotation of transcription start sites in the complete genome, as well as to the discovery of new core promoter sequence elements, two of which have been experimentally verified; (2) recognition of C. elegans microRNA genes, the gene products of which are tiny functional RNAs that inhibit the translation or lead to the degradation of specific target mRNAs; (3) a comparative model to detect alternative splicing events conserved between mammalian species.

Hosted by Elizabeth Bradley.

Department of Computer Science
University of Colorado Boulder
Boulder, CO 80309-0430 USA
May 5, 2012 (14:13)