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Colloquium - Winfree

Four Paradigms in DNA Computing
Princeton University

DNA computing studies how molecular chemistry can perform information processing tasks. This introduction to DNA Computing will focus on biochemical mechanisms available as computation primitives and will outline four approaches that combine those primitives to perform computation.

Adleman's original approach creates a combinatorial library of DNA sequences, and then performs a clever series of laboratory experiments to filter out the unwanted sequences. The algorithmic self-assembly approach encodes problems into a set of molecular "tiles" that assembly according to matching rules -- this potentially allows for Turing-universal computation in a single chemical reaction. If only we knew how to re-design complex enzymes, we could use the third approach: to actively "re-write" a single strand of DNA in ways not unlike transcription by polymerase or translation by ribosomes. The fourth approach not only borrows from biology but also hopes to give back to it by learning how to re-program genetic regulatory circuits using digital logic.

This talk will introduce some of the key ideas -- and people -- that are bringing DNA computers from theory towards reality.

Hosted by Grzegorz Rozenberg.
Refreshments will be served prior to the talk at 3:30pm.

Department of Computer Science
University of Colorado Boulder
Boulder, CO 80309-0430 USA
May 5, 2012 (14:13)