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home · events · colloquia · 2007-2008 · 
 

Colloquium - Yeo

 
4/28/2008
12:00pm-1:00pm
EKLC 338

Uncovering the Splicing Code and Alternative Splicing in Stem Cells
Salk Institute

Alternative pre-mRNA splicing affects a majority of human genes and plays important roles in development and disease. It has been estimated that at least 50% of human genes undergo alternative splicing (AS). Despite the prevalence of AS, many fundamental questions still lay unanswered. First, which of these events are biologically important? Can we distinguish biologically relevant alternative from constitutively spliced exons in the human genome? What are the salient features that are predictive of AS, and can we identify novel alternative events? Second, what are the functional cis-regulatory elements that regulate constitutive and alternative splicing? How do we systematically identify these elements? Third, very little is known about AS in a developmental context; can we identify events that are differentially spliced during neuronal specification of human embryonic stem cells? What is the splicing factor that regulates these events? What is the function of the factor? In an effort to address these questions, we have integrated and developed computational approaches from machine-learning, genome-wide assays such as CLIP-Seq, novel approaches in Exon Array analysis, and molecular and cellular methods.

Hosted by Debra Goldberg.
EKLC 338 is the CIRES Auditorium and is on the third floor of the Ekeley Sciences Building.


The Department holds colloquia throughout the Fall and Spring semesters. These colloquia, open to the public, are typically held on Thursday afternoons, but sometimes occur at other times as well. If you would like to receive email notification of upcoming colloquia, subscribe to our Colloquia Mailing List. If you would like to schedule a colloquium, see Colloquium Scheduling.

Sign language interpreters are available upon request. Please contact Stephanie Morris at least five days prior to the colloquium.

 
See also:
Department of Computer Science
College of Engineering and Applied Science
University of Colorado Boulder
Boulder, CO 80309-0430 USA
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